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Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication

โœ Scribed by Sato, Ayami; Saito, Yoshimasa; Sugiyama, Kazuo; Sakasegawa, Noriko; Muramatsu, Toshihide; Fukuda, Shinya; Yoneya, Mikiko; Kimura, Masaki; Ebinuma, Hirotoshi; Hibi, Toshifumi; Ikeda, Masanori; Kato, Nobuyuki; Saito, Hidetsugu


Book ID
120063505
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
634 KB
Volume
114
Category
Article
ISSN
0730-2312

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th