Histone deacetylases as targets for treatment of multiple diseases
β Scribed by Tang, Jinhua; Yan, Haidong; Zhuang, Shougang
- Book ID
- 120460734
- Publisher
- Portland Press
- Year
- 2013
- Tongue
- English
- Weight
- 267 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0143-5221
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## Abstract Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of nonhistone transcription regulatory proteins, thus modulating the expression of genes important for complex biological events. Dysregulation of HDACs and aberrant chromatin acetylation and deacetylatio
## Abstract Histone deacetylase (HDAC) activity was first discovered about 40 years ago, but it was not until the molecular identification of the first HDACs in 1996 that this family of enzymes gained prominence. In addition to histones, HDACs reverse lysine acetylation of various nonβhistone prote