Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogs of 5'-deoxy-5'-(methylthio)adenosine
✍ Scribed by Sufrin, Janice R.; Spiess, Arthur J.; Kramer, Debora L.; Libby, Paul R.; Miller, John T.; Bernacki, Ralph J.; Lee, Younha; Borchardt, Ronald T.; Porter, Carl W.
- Book ID
- 126993024
- Publisher
- American Chemical Society
- Year
- 1991
- Tongue
- English
- Weight
- 906 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Recent studies have shown that a loss of methylthioadenosine phosphorylase (__MTAP__) gene expression exerts a tumor‐promoting effect, including induction of invasiveness, enhanced cell proliferation, and resistance against cytokines. To date, the molecular mechanisms underlying these e