1,2,3-Tri-O-acetyl-5-deoxy-5-methylthio-β-d-ribofuranose
✍ Scribed by Jeckelmann, Jean-Marc ;Lüthi Nyffeler, Therese ;Altmann, Michael ;Bürgi, Hans-Beat ;Renaud, Philippe ;Hauser, Jürg
- Publisher
- International Union of Crystallography
- Year
- 2005
- Tongue
- English
- Weight
- 163 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
In the structure of the title compound, C 12 H 18 O 7 S, no alteration of the relative configuration compared with d-(À)-ribose is observed.
📜 SIMILAR VOLUMES
The molecule of the title compound, C 29 H 35 ClO 15 S, possesses normal geometric parameters. Intermolecular C-HÁ Á ÁO hydrogen-bond interactions are responsible for the supramolecular assembly of the complex molecules into a threedimensional framework.
## Abstract A new simple 3‐step synthesis of 1‐O‐acetyl‐2,3,5‐tri‐O‐benzoyl‐β‐Dribofuranoside is described. D‐Ribose is methylated to 1‐O‐methylribofuranoside and the latter benzoylated to 1‐O‐methyl‐2,3,5‐tri‐O‐benzoyl‐D‐ribofuranoside. Acetolysis with a mixture of acetic acid, acetic anhydride an
5-Dcoxy-J,2-O-isopropylidene-S-C-(methoxyphenylphosphinyl)-~-O-~~thyl-n-D-ribofuranose (4) was prepared from 1,2-0-isopropylidene-3-O-methyl-a-D-ribo-pentodialdo-1,4-furanose by an addition reaction with methyl phenylphosphinate, followed by deoxygenation of the terminal HO-$H-P group of the adduct
The title compound, C 51 H 56 N 4 O 21 Á0.1C 6 H 14 , crystallizes with two independent protected trisaccharide molecules and a partially occupied hexane solvent molecule in the asymmetric unit. The major conformational difference between the two trisaccharide molecules involves the O-acetyl group a