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Synthesis and antiproliferative effects of novel 5'-fluorinated analogs of 5'-deoxy-5'-(methylthio)adenosine

✍ Scribed by Sufrin, Janice R.; Spiess, Arthur J.; Kramer, Debora L.; Libby, Paul R.; Porter, Carl W.


Book ID
127249080
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
644 KB
Volume
32
Category
Article
ISSN
0022-2623

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## Abstract Recent studies have shown that a loss of methylthioadenosine phosphorylase (__MTAP__) gene expression exerts a tumor‐promoting effect, including induction of invasiveness, enhanced cell proliferation, and resistance against cytokines. To date, the molecular mechanisms underlying these e