Synthesis and antiproliferative effects of novel 5'-fluorinated analogs of 5'-deoxy-5'-(methylthio)adenosine
β Scribed by Sufrin, Janice R.; Spiess, Arthur J.; Kramer, Debora L.; Libby, Paul R.; Porter, Carl W.
- Book ID
- 127249080
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 644 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-2623
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pectively (e.g. for (2a) in CC14: v, , (CSj) = 1146vw, vs(CS2) = 61 9 cm-1 vs). Spectroscopic and X-ray data indicate pseudooctahedral environment of the metal in (/a)--( 2f) with (pseudo)-Czv symmetry. The IH-NMR spectra indicate in particular that an isomeric mixture containing (Ze) and a tolyldit
## Abstract Recent studies have shown that a loss of methylthioadenosine phosphorylase (__MTAP__) gene expression exerts a tumorβpromoting effect, including induction of invasiveness, enhanced cell proliferation, and resistance against cytokines. To date, the molecular mechanisms underlying these e