As&i-ma&i lachida-shi lbkyu Japan,
Synthetic studies on mitomycins synthesis of aziridino-pyrrolo(1,2-a)indoles.
β Scribed by Tadashi Hirata; Yasuhiro Yamada; Masanao Matsui
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 191 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Synthetic approaches toward mitomyoins (I) (1) have been made energetically by a Lederle group snd the synthesis of 7-methoxymitosene (II) was reported (2). However, their various
π SIMILAR VOLUMES
## Mitomycin antibiotics (I) have a novel ring system that is aziridinopyrrolo II 1,2-a indoloquinone(1). In synthetic studies on mitomycin analogs Lederle group synthesised 7-benzyloxy-9H-pyrrolo 1,2-a indole(2) and substituted 2,3r.
## Abstract A new method for the synthesis of pyrrolo[1,2β__a__]indoles, starting from enamines via 1,5βdipolar cyclization is described. The method is considered to be useful for the synthesis of mitomycin type of compounds.
## Abstract For Abstract see ChemInform Abstract in Full Text.
Considerable attention has been given during the last decade to some metabolic products of a group of Streptomyces, "the mitomycines", which show remarkable antibiotic and antitumoral activity.