Synthetic approaches toward mitomyoins (I) (1) have been made energetically by a Lederle group snd the synthesis of 7-methoxymitosene (II) was reported (2). However, their various
Synthetic studies on mitomycins part II. Synthesis of aziridino-pyrrolo(1,2-a) indoles.
β Scribed by Tadashi Hirata; Yasuhiro Yamada; Masanao Matsui
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 176 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
As&i-ma&i lachida-shi lbkyu Japan,
π SIMILAR VOLUMES
## Mitomycin antibiotics (I) have a novel ring system that is aziridinopyrrolo II 1,2-a indoloquinone(1). In synthetic studies on mitomycin analogs Lederle group synthesised 7-benzyloxy-9H-pyrrolo 1,2-a indole(2) and substituted 2,3r.
## Abstract A new method for the synthesis of pyrrolo[1,2β__a__]indoles, starting from enamines via 1,5βdipolar cyclization is described. The method is considered to be useful for the synthesis of mitomycin type of compounds.
A novel class of dihydro-and tetrahydroisoxazoloC3',I':3,4~pyrrolo~,2-a]indoles are synthesized via intramolecular nitrone andnitrileoxide cycloaddition reactions.
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