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Synthetic studies on substituted 9h-pyrrolo [1,2-a] indoles and 2,3-dihydro-1h-pyrrolo[1,2-a]indoles

โœ Scribed by Yasuhiro Yamada; Tadashi Hirata; Masanao Matsui


Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
160 KB
Volume
10
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Mitomycin

antibiotics (I) have a novel ring system that is aziridinopyrrolo II 1,2-a indoloquinone(1).

In synthetic studies on mitomycin analogs Lederle group synthesised 7-benzyloxy-9H-pyrrolo 1,2-a indole(2) and substituted 2,3r.


๐Ÿ“œ SIMILAR VOLUMES


Rearrangement of spiro[2H-1-benzopyran-2
โœ Vytas Martynaitis; Algirdas ล aฤkus; Ulf Berg ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 68 KB

## Abstract Heating of 1โ€ฒโ€(__N__โ€substituted carbamoyl)methylspiro[2__H__โ€1โ€benzopyranโ€2,2โ€ฒโ€[2__H__]indoles] with potassium hydroxide in ethanol yields diastereomeric 5a,13โ€methanoโ€6__H__โ€1,3โ€benzoxazepino[3,2โ€__a__]indoleโ€12โ€carboxโ€amides. Reduction of the latter with sodium borohydride affords 1,

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Synthetic approaches toward mitomyoins (I) (1) have been made energetically by a Lederle group snd the synthesis of 7-methoxymitosene (II) was reported (2). However, their various