Synthetic studies on substituted 9h-pyrrolo [1,2-a] indoles and 2,3-dihydro-1h-pyrrolo[1,2-a]indoles
โ Scribed by Yasuhiro Yamada; Tadashi Hirata; Masanao Matsui
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 160 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
Mitomycin
antibiotics (I) have a novel ring system that is aziridinopyrrolo II 1,2-a indoloquinone(1).
In synthetic studies on mitomycin analogs Lederle group synthesised 7-benzyloxy-9H-pyrrolo 1,2-a indole(2) and substituted 2,3r.
๐ SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Heating of 1โฒโ(__N__โsubstituted carbamoyl)methylspiro[2__H__โ1โbenzopyranโ2,2โฒโ[2__H__]indoles] with potassium hydroxide in ethanol yields diastereomeric 5a,13โmethanoโ6__H__โ1,3โbenzoxazepino[3,2โ__a__]indoleโ12โcarboxโamides. Reduction of the latter with sodium borohydride affords 1,
Synthetic approaches toward mitomyoins (I) (1) have been made energetically by a Lederle group snd the synthesis of 7-methoxymitosene (II) was reported (2). However, their various