## Mitomycin antibiotics (I) have a novel ring system that is aziridinopyrrolo II 1,2-a indoloquinone(1). In synthetic studies on mitomycin analogs Lederle group synthesised 7-benzyloxy-9H-pyrrolo 1,2-a indole(2) and substituted 2,3r.
(1R,2R)-Ethyl 1-azido-2-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indole-9-carboxylate
✍ Scribed by Fernandes, Manuel A. ;de Koning, Charles B. ;Michael, Joseph P. ;Petersen, Riaan L.
- Publisher
- International Union of Crystallography
- Year
- 2005
- Tongue
- English
- Weight
- 227 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1600-5368
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📜 SIMILAR VOLUMES
In the title compound, C 22 H 15 NO 3 , the quinoline system is essentially planar, and the mean plane of the indenone ring system is almost coplanar with the quinoline group. The crystal structure is stabilized by inter-and intramolecular C-HÁ Á ÁO hydrogen-bonding interactions.
The two pyrrolidine rings in the title compound, C~25~H~22~N~2~O~6~, adopt envelope conformations. Molecules are stabilized by intramolecular O—H...O hydrogen bonds, and linked into centrosymmetric dimers by intermolecular N—H...O hydrogen bonds.