Synthesis of pyrrolo[1,2-a]benzo[f]indole derivatives.
✍ Scribed by Vincenzo Carelli; Mario Cardellini; Flaviano Morlacchi
- Publisher
- Elsevier Science
- Year
- 1967
- Tongue
- French
- Weight
- 210 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Considerable attention has been given during the last decade to some metabolic products of a group of Streptomyces, "the mitomycines", which show remarkable antibiotic and antitumoral activity.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
A new family of pyrrolo[1,2:1%,2%]azepino [5,6-b]indole derivatives 8,15 related to anthramycin skeleton was prepared in good yield from indole-2-carboxylic acid and b-aminoesters 4 through intramolecular cyclisation.
## Abstract Heating of 1′‐(__N__‐substituted carbamoyl)methylspiro[2__H__‐1‐benzopyran‐2,2′‐[2__H__]indoles] with potassium hydroxide in ethanol yields diastereomeric 5a,13‐methano‐6__H__‐1,3‐benzoxazepino[3,2‐__a__]indole‐12‐carbox‐amides. Reduction of the latter with sodium borohydride affords 1,
A2-Pyrrolin-4-ones 12 and 73, prepared from 7 -acyl-3-alkyl-1,3-dihydro-2Kindol-2-ones 7, via the corresponding 3-bromo-, 2 and 6,3-azido, 7 and 8, and 3-iminophosphorane 9 and 10, were cyclized to the corresponding pyrrolo[l,2-c]quinazoline derivatives 14 and 15.