✍ Scribed by Dean P Stamos; Yoshito Kishi
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📜 SIMILAR VOLUMES
An efficient synthesis of the C.27-C.38 segment of halichondrins is accomplished, using the Ireland-Claisen rearrangement, Ni(ll)lCr(Il)-mediated coupling and Michael reactions as the key steps.
A stereocontrolled and practical synthetic route to the acetal 2a, a degradation product of palytoxin, in optically active form is described. Palytoxin, the toxic principle isolated from marine soft corals of the genus Palythoa, is the most poisonous substance known to date, except for a few polype
An 8-step synthesis of the bicyclic ketal 2 from l-(+)-citronella1 is described. -
A stereocontrolled 12-step synthesis of the C.85-C.98 segment of palytoxin is described, Recent work in this laboratory has established the complete structure and laid a solid foundation for the chemical synthesis of the structurally novel and highly physioloqically active marine natural product pal
The Ct-Ct3 segment 6 of concanamycin A (1) was prepared by a highly stereocontrolled route (87% overall ds) in 16 steps from the ester 9. Key steps are the one-pot aldol/reduction, 8 + 12, and the HWB reaction, 18 + 19 + 6.8 1997 Elsevier Science Ltd.