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Synthetic studies on palytoxin. Stereocontrolled, practical synthesis of the C.101–C.115 segment

✍ Scribed by Soo Sung Ko; Larry L Klein; Klaus-Peter Pfaff; Yoshito Kishi

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
225 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereocontrolled and practical synthetic route to the acetal 2a, a degradation product of palytoxin, in optically active form is described.

Palytoxin, the toxic principle isolated from marine soft corals of the genus Palythoa, is the most poisonous substance known to date, except for a few polypeptides and proteins found in bacteria and plants.

Pioneering investigations by the Hawaii group2 and by the Naqoya group3 recently led them independently to suggest the gross structure 1 for palytoxin. 4 Related to our -

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Synthetic studies on palytoxin stereocon
Synthetic studies on palytoxin stereocontrolled practical synthesis of the C.85 – C.98 segment
✍ W.W. McWhorter Jr.; S.H. Kang; Y. Kishi 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 184 KB

A stereocontrolled 12-step synthesis of the C.85-C.98 segment of palytoxin is described, Recent work in this laboratory has established the complete structure and laid a solid foundation for the chemical synthesis of the structurally novel and highly physioloqically active marine natural product pal