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Synthetic Studies towards Halichondrins: Synthesis of the C.27–C.38 Segment

✍ Scribed by Thomas D. Aicher; Keith R. Buszek; Francis G. Fang; Craig J. Forsyth; Sun Ho Jung; Yoshito Kishi; Paul M. Scola

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 277 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)91671-x

No coin nor oath required. For personal study only.

✦ Synopsis

An efficient synthesis of the C.27-C.38 segment of halichondrins is accomplished, using the Ireland-Claisen rearrangement, Ni(ll)lCr(Il)-mediated coupling and Michael reactions as the key steps.

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