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Synthetic Studies Towards Halichondrins: Synthesis of the Left Half of Halichondrins

โœ Scribed by Keith R. Buszek; Francis G. Fang; Craig J. Forsyth; Sung Ho Jung; Yoshito Kishi; Paul M. Scola; Suk Kyoon Yoon

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
226 KB
Volume
33
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

An efficient synthesis of the left half of halichondrins B and C is reported.

๐Ÿ“œ SIMILAR VOLUMES

Synthetic Studies towards Halichondrins:
Synthetic Studies towards Halichondrins: Synthesis of the C.27โ€“C.38 Segment
โœ Thomas D. Aicher; Keith R. Buszek; Francis G. Fang; Craig J. Forsyth; Sun Ho Jun ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 277 KB

An efficient synthesis of the C.27-C.38 segment of halichondrins is accomplished, using the Ireland-Claisen rearrangement, Ni(ll)lCr(Il)-mediated coupling and Michael reactions as the key steps.

A synthesis of the C1โ€“C15 domain of the
A synthesis of the C1โ€“C15 domain of the halichondrins
โœ Katrina L. Jackson; James A. Henderson; Jonathan C. Morris; Hajime Motoyoshi; An ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 125 KB

A concise route to the C1-C15 domain of the halichondrins is described. The key reaction is the conversion of a furfuryl alcohol to a pyranone. The stereocenter of this pyranone serves as the starting point for the other 8 stereocenters.