𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Ψ[CH(CN)NH] pseudopeptides. A new peptide bond surrogate

✍ Scribed by Rosario Herranz; M.Luisa Suárez-Gea; Soledad Vinuesa; M.Teresa García-López; Ana Martínez

Book ID
103399057
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
252 KB
Volume
32
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Direct synthesis of N-protected β-amino
Direct synthesis of N-protected β-amino dimethylhydroxamates: Application to the solid-phase synthesis of a peptide incorporating a new amide bond surrogate Ψ[CH2CH2NH]
✍ David Limal; Anne Quesnel; Jean-Paul Briand 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 224 KB

A rapid and efficient one-step synthesis of N-protected fl-amino dimethylhydroxamates starting from diazo ketones is reported A Fmoc-protected fl-amino aldehyde obtained by reduction of its corresponding dimethylhydroxamate was incorporated during solid phase assembly of an antigenic peptide. The re

Solid phase synthesis of a ΨCH2NH pseudo
Solid phase synthesis of a ΨCH2NH pseudopeptide by ligation of a peptidyl aldehyde with a resin-bound amino peptide
✍ Christel Gros; Nathalie Galéotti; Robert Pascal; Patrick Jouin 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 571 KB

Solid phase synthesis of W[CH2NH] pseudopeptide 3 was accomplished by reductive amination of peptidyl aldehyde 1 with resin bound amino peptide 2. No epimerization took place during the aldehyde preparation or the reductive amination step. This convergent strategy should facilitate the synthesis of

Transition state isosteres of the γ-glut
Transition state isosteres of the γ-glutamyl peptide bond hydrolysis: synthesis and characterization of the ψ[CH2NH] pseudopeptide analogue of glutathione
✍ Ivana Cacciatore; Antonio Di Stefano; Grazia Luisi; Francesco Pinnen; Piera Sozi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB

## Abstract The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the γ‐Glu‐Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright © 2003 European Peptide Society and John Wiley

“Carba” peptide bond surrogates: synthes
“Carba” peptide bond surrogates: synthesis of Boc-L-Leu-…(CH2-CH2)-L-Phe-OH and Boc-LLeu-ψ-(CH2-CH2)-D-Phe-OH through a horner-emmons reaction.
✍ Marc Rodriguez; Annie Heitz; Jean Martinez 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 265 KB

## Abstra A synthesis of Boc-L-Leu-\r(CHz-CHz&Phe-OH and Boc-~-L~u-u~(CH~-CH~)-Q-Phe-OH from Boc-ghomo-L-leucinal, through a Horner-Emmons reaction with ethyl 2-(diethylphosphono)-3-phenylpropionate is described. Intermediate cyclisation into lactames (3S,6R)-3-benzyl6-isobutyl-piperidin-2-one and