A systematic approach to the solid-phase synthesis of linear and cyclic pseudopeptide libraries containing ψ[CH2NH] amide bond surrogates

Direct synthesis of N-protected β-amino

Direct synthesis of N-protected β-amino dimethylhydroxamates: Application to the solid-phase synthesis of a peptide incorporating a new amide bond surrogate Ψ[CH2CH2NH]

✍ David Limal; Anne Quesnel; Jean-Paul Briand 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 224 KB

A rapid and efficient one-step synthesis of N-protected fl-amino dimethylhydroxamates starting from diazo ketones is reported A Fmoc-protected fl-amino aldehyde obtained by reduction of its corresponding dimethylhydroxamate was incorporated during solid phase assembly of an antigenic peptide. The re