✦ LIBER ✦
Direct synthesis of N-protected β-amino dimethylhydroxamates: Application to the solid-phase synthesis of a peptide incorporating a new amide bond surrogate Ψ[CH2CH2NH]
✍ Scribed by David Limal; Anne Quesnel; Jean-Paul Briand
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 224 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A rapid and efficient one-step synthesis of N-protected fl-amino dimethylhydroxamates starting from diazo ketones is reported A Fmoc-protected fl-amino aldehyde obtained by reduction of its corresponding dimethylhydroxamate was incorporated during solid phase assembly of an antigenic peptide. The resulting pseudopeptide containing an ethylene amino bond ~F[CH2CH2NH] was efficiently recovered.