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Solid phase synthesis of a ΨCH2NH pseudopeptide by ligation of a peptidyl aldehyde with a resin-bound amino peptide

✍ Scribed by Christel Gros; Nathalie Galéotti; Robert Pascal; Patrick Jouin

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
571 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

Solid phase synthesis of W[CH2NH] pseudopeptide 3 was accomplished by reductive amination of peptidyl aldehyde 1 with resin bound amino peptide 2. No epimerization took place during the aldehyde preparation or the reductive amination step. This convergent strategy should facilitate the synthesis of analogues of the neuropeptide PACAP.

📜 SIMILAR VOLUMES

Direct synthesis of N-protected β-amino
Direct synthesis of N-protected β-amino dimethylhydroxamates: Application to the solid-phase synthesis of a peptide incorporating a new amide bond surrogate Ψ[CH2CH2NH]
✍ David Limal; Anne Quesnel; Jean-Paul Briand 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 224 KB

A rapid and efficient one-step synthesis of N-protected fl-amino dimethylhydroxamates starting from diazo ketones is reported A Fmoc-protected fl-amino aldehyde obtained by reduction of its corresponding dimethylhydroxamate was incorporated during solid phase assembly of an antigenic peptide. The re