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Transition state isosteres of the γ-glutamyl peptide bond hydrolysis: synthesis and characterization of the ψ[CH2NH] pseudopeptide analogue of glutathione

✍ Scribed by Ivana Cacciatore; Antonio Di Stefano; Grazia Luisi; Francesco Pinnen; Piera Sozio

Book ID: 105360315
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 100 KB
Volume: 10
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.501

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✦ Synopsis

Abstract

The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the γ‐Glu‐Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

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