Efficient Synthesis of γ-Oxo-and γ-Hydroxy-α-amino Acids. -Reduction of aminoester (Va) with Zn(BH 4 ) 2 permits intermediate isolation of the γ-hydroxy derivative, which is converted to lactone (IX) during silica gel chromatography. -(MERLA, B.;
Synthesis of α-Amino-γ-hydroxy Acids: γ,γ'-Dihydroxyvaline
✍ Scribed by Galantay, Eugene; Szabo, Attila; Fried, Josef
- Book ID
- 127374673
- Publisher
- American Chemical Society
- Year
- 1963
- Tongue
- English
- Weight
- 711 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A lacile slereoselcctive melhod Ior the synthesis of y-substituted, y-mnino acids from of amino acids was developed. The key step of the procedurc is complete reduction of Ihe keto functionality of ot-~unino acyl Meldruln's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid
Ihe amino acids (-)-erythro-and (-)-threo-ylqdrcqnorvaline have been synthesized fran D-ribonolactone, 6, as single chira-cursor. Moreover, S-hydroxy-uazido-rvalerolactones 1Za and 12b have been also prepared from 6 in two different alternative ways. These compounds afford B,y-dihydroxy~~-amino aci