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Stereoselective Synthesis of γ-hydroxy-α-amino acids via intramolecular amidomercuration
✍ Scribed by Kenn E. Harding; Thomas H. Marman; Do-hyun Nam
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 1021 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
A lacile slereoselcctive melhod Ior the synthesis of y-substituted, y-mnino acids from of amino acids was developed. The key step of the procedurc is complete reduction of Ihe keto functionality of ot-~unino acyl Meldruln's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid
Facile Stereoselective Synthesis of γ-Substituted γ-Amino Acids from the Corresponding α-Amino Acids. -The mild and short procedure presented is compatible with common side-chain protecting groups, sensitive functionalities and preserves the chirality of the starting α-amino acid.