Synthesis of Highly Functionalized Amino Acid and Hydroxy Acid Derivatives from γ-Aminoalkyl-Substituted α-Methylene-γ-butyrolactones
✍ Scribed by Steffen Steurer; Joachim Podlech
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 641 KB
- Volume
- 2002
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
The indium-mediated reaction of Z-protected α-amino transformation of the amino aldehydes. Acid-catalyzed esterification (H 2 SO 4 in Et 2 O) led to α-methylene-γaldehydes 1-6 with 2-(bromomethyl)acrylates 8/9 in aqueous solvents has been investigated. The preference for the butyrolactones 17-22 wit
Aminoalkyl-Substituted α-Methylene-γ-butyrolactones from α-Amino Acids Using an Indium-Mediated Barbier Allyl Addition. α-Amino aldehydes, prepared from α-amino acids, can be cleanly transformed into esters of type (III) in high yields and without racemization by In-induced Barbier reaction. The di
Facile Stereoselective Synthesis of γ-Substituted γ-Amino Acids from the Corresponding α-Amino Acids. -The mild and short procedure presented is compatible with common side-chain protecting groups, sensitive functionalities and preserves the chirality of the starting α-amino acid.