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Synthesis of vinyl pyrophosphonate analogues of farnesyl pyrophosphate: New potential inhibitors of farnesyl protein transferase

✍ Scribed by Ibrahim Zgani; Chantal Menut; Jean Louis Montéro

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
127 KB
Volume
13
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The synthesis of new bioisosteric analogues of farnesyl pyrophosphate where a vinyl pyrophosphonate replaced the pyrophosphate moiety is described. These compounds have been prepared using a Horner–Wadsworth–Emmons procedure and a modified Michelson reaction. They have been evaluated for the inhibition of farnesyl protein transferase. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:654–661, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10081

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