ChemInform Abstract: Synthesis of Triphosphonate Analogues of Farnesyl Pyrophosphate. Inhibitors of Squalene Synthase and Protein:Farnesyl Transferase.
β Scribed by M. OVERHAND; E. PIETERMAN; L. H. COHEN; A. R. P. M. VALENTIJN; G. A. VAN DER MAREL; J. H. VAN BOOM
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 23 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,