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ChemInform Abstract: Imidazole-Containing Diarylether and Diarylsulfone Inhibitors of Farnesyl-Protein Transferase.

✍ Scribed by Christopher J. Dinsmore; Theresa M. Williams; Timothy J. O'Neill; Dongming Liu; Elaine Rands; J. Christopher Culberson; Robert B. Lobell; Kenneth S. Koblan; Nancy E. Kohl; Jackson B. Gibbs

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
31
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable via the β€œReferences” option.

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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,