ChemInform Abstract: Non-Thiol 3-Aminomethylbenzamide Inhibitors of Farnesyl-Protein Transferase.
β Scribed by Christopher J. Dinsmore; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,