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ChemInform Abstract: Stereospecific Synthesis of a Novel Farnesyl Protein Transferase Inhibitor, Valinoctin A and Its Analogues.

✍ Scribed by M. TSUDA; Y. MURAOKA; T. TAKEUCHI; R. SEKIZAWA; K. UMEZAWA

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199713174

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✦ Synopsis

Stereospecific Synthesis of a Novel Farnesyl Protein Transferase Inhibitor, Valinoctin A and Its Analogues.

-The valinoctin A analogue (VIII), prepared via Curtius rearrangement of an intermediate azide, shows essentially the same inhibitory activity as the parent compound. -

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