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ChemInform Abstract: Stereospecific Synthesis and Biological Evaluation of Farnesyl Diphosphate Isomers.

✍ Scribed by Ying Shao; Jeffrey T. Eummer; Richard A. Gibbs

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Stereospecific Synthesis and Biological Evaluation of Farnesyl Diphosphate Isomers.

-The diphosphates (Ia) and (II) are found to be very potent substrates for mammalian protein-farnesyl transferase. The isomer (Ib) is a submicromolar inhibitor of the transferase. -(SHAO, YING; EUMMER,

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