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ChemInform Abstract: Synthesis and Conformational Analysis of Di-13C-Labeled Farnesyl Diphosphate Analogues

โœ Scribed by T. J. ZAHN; M. B. KSEBATI; R. A. GIBBS


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Stereospecific Synt
โœ Ying Shao; Jeffrey T. Eummer; Richard A. Gibbs ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 27 KB ๐Ÿ‘ 1 views

Stereospecific Synthesis and Biological Evaluation of Farnesyl Diphosphate Isomers. -The diphosphates (Ia) and (II) are found to be very potent substrates for mammalian protein-farnesyl transferase. The isomer (Ib) is a submicromolar inhibitor of the transferase. -(SHAO, YING; EUMMER,