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Arteminolides B, C, and D, New Inhibitors of Farnesyl Protein Transferase from Artemisia argyi.

โœ Scribed by Seung-Ho Lee; Hyae-Kyeong Kim; Jeong-Min Seo; Hyun-Mi Kang; Jong Han Kim; Kwang-Hee Son; Heesoon Lee; Byoung-Mog Kwon; Jongheon Shin; Youngwan Seo

Publisher
John Wiley and Sons
Year
2003
Weight
78 KB
Volume
34
Category
Article
ISSN
0931-7597

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Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,