𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Vigabatrin®.

✍ Scribed by Meng-Yang Chang; Chun-Yu Lin; Chi-Wi Ong


Book ID
101993098
Publisher
John Wiley and Sons
Year
2007
Weight
18 KB
Volume
38
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of carbon-14 labeled vigabatri
✍ Albert J. Schuster; Eugene R. Wagner 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 191 KB

## Abstract Carbon‐14 labeled vigabatrin was synthesized in 5 steps from 5‐hydroxymethyl‐2‐pyrrolidone tosylate and NaCN‐[^14^C]. A key step involved reduction of the resulting nitrile in the presence of excess dimethylamine to give the dimethylamino‐ethyl 2‐pyrrolidone derivative in one step. This

An efficient synthesis of carbon-14 labe
✍ Harpal S. Gill 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 229 KB

Vigabatrin-[6-14C] ((R,S)-4-amino-5-hexenoic-[6-14C] acid) was synthesized by employing Wittig condensation of 1-(1- butenyl)-2-oxo-5-pyrolidinecarboxaldehyde with methyl-[ 14C]-triphenylphosphonium iodide as the key step. The synthetic sequence involved 3 steps and produced the title compound in 70