Asymmetric synthesis of both enantiomers
✍
Wei Zhong-Yong; Edward E. Knaus
📂
Article
📅
1994
🏛
Elsevier Science
🌐
French
⚖ 763 KB
Both enantiomers of the potent GABA-T inhibitor, 4-amino-S-hexenoic acid (2), were prepared in five steps from (IQ-or (S)-methionine using a one-pot reduction-homologation of an a-amino ester as the key reaction step.