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Asymmetric synthesis of both enantiomers of vigabatrin®: An approach using methionine as the chiral pool

✍ Scribed by Wei Zhong-Yong; Edward E. Knaus

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 763 KB
Volume: 50
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)85629-5

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✦ Synopsis

Both enantiomers of the potent GABA-T inhibitor, 4-amino-S-hexenoic acid (2), were prepared in five steps from (IQ-or (S)-methionine using a one-pot reduction-homologation of an a-amino ester as the key reaction step.

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