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Asymmetric synthesis of anti-convulsive drug (S)-Vigabatrin®

✍ Scribed by S. Chandrasekhar; Suchismita Mohapatra

Book ID
108386964
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
156 KB
Volume
39
Category
Article
ISSN
0040-4039

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Asymmetric synthesis of (S)-vigabatrin®
Asymmetric synthesis of (S)-vigabatrin® and (S)-dihydrokavain via cobalt catalyzed hydrolytic kinetic resolution of epoxides
✍ I. Victor Paul Raj; A. Sudalai 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 108 KB

A concise route to the asymmetric synthesis of (S)-vigabatrin Ò and (S)-dihydrokavain has been described using Co-catalyzed hydrolytic kinetic resolution of racemic epoxides and regiospecific opening of terminal epoxides with dimethylsulfonium methylide as the key steps.