Asymmetric synthesis of (S)-vigabatrin® and (S)-dihydrokavain via cobalt catalyzed hydrolytic kinetic resolution of epoxides

✍ Scribed by I. Victor Paul Raj; A. Sudalai

• Book ID: 104095095
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 108 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.02.064

✦ Synopsis

A concise route to the asymmetric synthesis of (S)-vigabatrin Ò and (S)-dihydrokavain has been described using Co-catalyzed hydrolytic kinetic resolution of racemic epoxides and regiospecific opening of terminal epoxides with dimethylsulfonium methylide as the key steps.