Novel Asymmetric Synthesis of ( S )-Esmolol Using Hydrolytic Kinetic Resolution
✍ Scribed by Narsaiah, A. Venkat; Kumar, J. Kranthi
- Book ID
- 118206284
- Publisher
- Taylor and Francis Group
- Year
- 2011
- Tongue
- English
- Weight
- 193 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0039-7911
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A concise route to the asymmetric synthesis of (S)-vigabatrin Ò and (S)-dihydrokavain has been described using Co-catalyzed hydrolytic kinetic resolution of racemic epoxides and regiospecific opening of terminal epoxides with dimethylsulfonium methylide as the key steps.
A single enantiomer of a (stereo)chemically labile allylic-homoallylic alcohol was obtained in 91% e.e. and 96% yield from the racemate by employing a lipase-catalysed kinetic resolution coupled to in situ inversion under carefully controlled (Mitsunobu) conditions in order to suppress side reaction