✦ LIBER ✦

Synthesis of unlabelled and tritium labelled 4-isothiocyanato-1-(1-phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex.

✍ Scribed by Joannes T. M. Linders; Brian R. de Costa; Neile A. Grayson; Kenner C. Rice

Book ID: 102901461
Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 656 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310906

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of high specific activity tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine ([^3^H]fourphit), a probe for the autoradiographic study of the dopamine reuptake complex, is described. An improved, facile synthesis of unlabelled fourphit in high overall yield is also presented. Detailed study of the interaction of unlabelled and tritium labelled fourphit with the dopamine reuptake complex may lead to a better understanding of the actions of cocaine.

📜 SIMILAR VOLUMES

Synthesis of tritium labelled 4-fluoro-1

Synthesis of tritium labelled 4-fluoro-1-[1–(2-thienyl)]cyclohexylpiperidine ([3H]-FTCP); a tool for autoradiographic study of the phencyclidine binding site

✍ Andrew Thurkauf; Brian R. De Costa; Dale O. Kiesewetter; Arthur E. Jacobson; Ken 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 270 KB 👁 1 views

## 4-Fluoro -l-[l-(2-thienyl)-3-cyclohexenyl)lpiperidine was efficiently synthesized in four steps starting from cyclohexane-1,4-dione monoethylene ketal. Catalytic tritiation of this key intermediate in the final step afforded the title compound.

Synthesis of high specific activity (3,4

Synthesis of high specific activity (3,4-[3H]cyclohexyl)-N-[1 (2-benzo[b]thienyl)cyclohexyl]piperidine {[3H]BTCP}: A selective probe for the dopamine-reuptake complex

✍ Brian R. de Costa 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 455 KB 👁 1 views

High specific activity [3H]BTCP, a radioligand for the dopaminereuptake complex was synthesized in 7-steps starting with the readily available starting materials, cyclohexane-l,4-dione monoethylene ketal and benzo[b]thiophene; the tritium label was introduced in the final step on the 3-and 4-positio

Synthesis and evaluation of [3H]-4-fluor

Synthesis and evaluation of [3H]-4-fluoro-1-[1-(3-hydroxyphenyl)cyclohexyl]piperidine, a potential tool for autoradiographic study of the phencyclidine receptor

✍ Brian R. de Costa; Mariena V. Mattson 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 554 KB

An expedient synthesis of high specific

An expedient synthesis of high specific activity tritium labelled 4-fluoro-1-[1-(2-thienyl)]cyclohexylpiperidine ([3H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex

✍ Neile A. Grayson; Brian R. de Costa; Joannes T. M. Linders; Kenner C. Rice 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 319 KB 👁 1 views

## Abstract [^18^F]4‐Fluoro‐1‐[1‐(2‐thienyl)cyclohexyl)]piperidine is a ligand potentially useful for positron emission tomography of the PCP/NMDA receptor complex in the mammalian brain. The tritium‐labelled title compound was synthesized in 5 steps starting with cyclohexanone. Catalytic tritiolys