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Synthesis of high specific activity (3,4-[3H]cyclohexyl)-N-[1 (2-benzo[b]thienyl)cyclohexyl]piperidine {[3H]BTCP}: A selective probe for the dopamine-reuptake complex

✍ Scribed by Brian R. de Costa

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
455 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

High specific activity [3H]BTCP, a radioligand for the dopaminereuptake complex was synthesized in 7-steps starting with the readily available starting materials, cyclohexane-l,4-dione monoethylene ketal and benzo[b]thiophene; the tritium label was introduced in the final step on the 3-and 4-positions of the cyclohexyl ring by catalytic tritiation of N-[4-(2benzo[b]thienyl)cyclohexenyl]piperidine to give [3H]BTCP in 7.3% yield with a specific activity of 29.8 Ci/mmol (51.4% isotopic incorporation).

📜 SIMILAR VOLUMES

An expedient synthesis of high specific
An expedient synthesis of high specific activity tritium labelled 4-fluoro-1-[1-(2-thienyl)]cyclohexylpiperidine ([3H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex
✍ Neile A. Grayson; Brian R. de Costa; Joannes T. M. Linders; Kenner C. Rice 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 319 KB

## Abstract [^18^F]4‐Fluoro‐1‐[1‐(2‐thienyl)cyclohexyl)]piperidine is a ligand potentially useful for positron emission tomography of the PCP/NMDA receptor complex in the mammalian brain. The tritium‐labelled title compound was synthesized in 5 steps starting with cyclohexanone. Catalytic tritiolys