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An expedient synthesis of high specific activity tritium labelled 4-fluoro-1-[1-(2-thienyl)]cyclohexylpiperidine ([3H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex

✍ Scribed by Neile A. Grayson; Brian R. de Costa; Joannes T. M. Linders; Kenner C. Rice

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
319 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[^18^F]4‐Fluoro‐1‐[1‐(2‐thienyl)cyclohexyl)]piperidine is a ligand potentially useful for positron emission tomography of the PCP/NMDA receptor complex in the mammalian brain. The tritium‐labelled title compound was synthesized in 5 steps starting with cyclohexanone. Catalytic tritiolysis in the final step afforded the title compound in high radiochemical yield and specific activity. This method represents a more efficient approach than previously published syntheses.

📜 SIMILAR VOLUMES

Synthesis of tritium labelled 4-fluoro-1
Synthesis of tritium labelled 4-fluoro-1-[1–(2-thienyl)]cyclohexylpiperidine ([3H]-FTCP); a tool for autoradiographic study of the phencyclidine binding site
✍ Andrew Thurkauf; Brian R. De Costa; Dale O. Kiesewetter; Arthur E. Jacobson; Ken 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 270 KB

## 4-Fluoro -l-[l-(2-thienyl)-3-cyclohexenyl)lpiperidine was efficiently synthesized in four steps starting from cyclohexane-1,4-dione monoethylene ketal. Catalytic tritiation of this key intermediate in the final step afforded the title compound.