## 4-Fluoro -l-[l-(2-thienyl)-3-cyclohexenyl)lpiperidine was efficiently synthesized in four steps starting from cyclohexane-1,4-dione monoethylene ketal. Catalytic tritiation of this key intermediate in the final step afforded the title compound.
Synthesis and evaluation of [3H]-4-fluoro-1-[1-(3-hydroxyphenyl)cyclohexyl]piperidine, a potential tool for autoradiographic study of the phencyclidine receptor
β Scribed by Brian R. de Costa; Mariena V. Mattson
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 554 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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~F]-1-(3-Fluoropropyl)-4-(4-cyanophenoxymethyl)piperidine has been prepared as a potential sigma-I receptor ligand for PET. The unlabeled ligand was found to be selective in vitro for the sigma-I receptor [Ki(crl) = 4.3 nM] when tested in a variety of neuroreceptor binding assays. Furthermore, the l
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
High specific activity [3H]BTCP, a radioligand for the dopaminereuptake complex was synthesized in 7-steps starting with the readily available starting materials, cyclohexane-l,4-dione monoethylene ketal and benzo[b]thiophene; the tritium label was introduced in the final step on the 3-and 4-positio
## Abstract [^18^F]4βFluoroβ1β[1β(2βthienyl)cyclohexyl)]piperidine is a ligand potentially useful for positron emission tomography of the PCP/NMDA receptor complex in the mammalian brain. The tritiumβlabelled title compound was synthesized in 5 steps starting with cyclohexanone. Catalytic tritiolys