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ChemInform Abstract: Synthesis of N-Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (.+-.)-3-(4-Hydroxyphenyl)pyrrolidines: Selective Antagonists at the 1A/2B NMDA Receptor Subtype.

✍ Scribed by Richard M. Woodward; et al. et al.


Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
31
Category
Article
ISSN
0931-7597

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Abstract

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ChemInform Abstract: Spiro-Substituted P
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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (Β±)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and Evaluation of NK 1 -NK 2 Dual Antagonistic Activities. -In order to obtain more potent NK 1 -NK 2 dual antagonists a