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ChemInform Abstract: Synthesis and NK1 Receptor Antagonistic Activity of (.+-.)-1-Acyl-3-(3,4-dichlorophenyl)-3-[2-(spiro-substituted piperidin-1′-yl)ethyl]piperidines.

✍ Scribed by H. KUBOTA; Y. OKAMOTO; M. FUJII; K. IKEDA; M. TAKEUCHI; T. SHIBANUMA; Y. ISOMURA

Publisher
John Wiley and Sons
Year
2010
Weight
39 KB
Volume
29
Category
Article
ISSN
0931-7597

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✍ Hirokazu Kubota; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (±)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and Evaluation of NK 1 -NK 2 Dual Antagonistic Activities. -In order to obtain more potent NK 1 -NK 2 dual antagonists a