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Synthesis of tylonolide, the aglycone of tylosin

โœ Scribed by Masamune, Satoru; Lu, Linda D. L.; Jackson, William P.; Kaiho, Tatsuo; Toyoda, Tatsuo


Book ID
126934174
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
516 KB
Volume
104
Category
Article
ISSN
0002-7863

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๐Ÿ“œ SIMILAR VOLUMES


Total synthesis of tylonolide, the aglyc
โœ Tatsuyoshi Tanaka; Yuji Oikawa; Tatsuo Hamada; Osamu Yonemitsu ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 286 KB

Segments i (Cll-C17) and ii (Cl-ClO), synthesized from D-glucose by employing some stereoselective reactions and benzyl-type protecting groups, were esterified and cyclized to the 16-membered enone, which was readily converted to tylonolide, the aglycone of tylosin. Tylosin is a typical 16-membered

Total synthesis of tylonolide, an aglyco
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The total synthesis of tylonolide, a 16-membered-ring aglycone of a macrolide antibiotic, tylosin, has been accomplished by coupling two segments of Cl-Cl0 and Cll-Cl7 portions, which are stereospecifically derived from D-glucose. Josamycin (leucomycin A3) and tylosin (4) constitute the medicinally

Synthesis of the right hand fragment of
โœ Linda D.-L. Lu ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 256 KB

The synthesis of the lactonic thioester 5, corresponding to the C(l)-C( 9) fragment of tylonolide hemiacetal, via the bicyclic ester 5 , is described.

Total synthesis of tylosin
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Tylosln has been synthesized by reglo-and stereoselectlve lntroductlon of the amino dlsaccharlde moiety and D-mycrnose onto the previously synthesized 16-membered-ring aglycone. Tylosln (1)) a 16-membered-ring macrohde antlblotlc, IS extremely used as a therapeutrc substance in treatment of mycoplas