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Tylonolide hemiacetal, the aglycone of tylosin and its partial synthesis

✍ Scribed by Masamune, Satoru; Hayase, Yoshio; Chan, Wan Kit; Sobczak, Ronald L.


Book ID
121334987
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
262 KB
Volume
98
Category
Article
ISSN
0002-7863

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Segments i (Cll-C17) and ii (Cl-ClO), synthesized from D-glucose by employing some stereoselective reactions and benzyl-type protecting groups, were esterified and cyclized to the 16-membered enone, which was readily converted to tylonolide, the aglycone of tylosin. Tylosin is a typical 16-membered