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Synthesis of tritium-labelled natural prostaglandins of series 1,2,3

✍ Scribed by V. P. Shevchenko; G. I. Myagkova; T. Yu. Lazurkina; P. M. Dyomin; S. I. Shram; D. A. Zabolotsky; I. Yu. Nagayev; Yu. Yu. Belosludtsev; R. P. Evstigneeva; N. F. Myasoyedov

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
678 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

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The complete chemical synthesis of unsaturated precursors of eicosanoids of series 1,2,3 is described. Selective hydrogenation by gaseous tritium of eicosapolyenoic acid acetylenic analogues was used to introduce the label into dihomo-r-linolenic, arachidonic and timnodonic acids, from which f H ) G E , fH)PGD and rH]TXB2 were obtained by biosynthesis, From L3H ]PGE multiply labelled PGA, PGB, PGFa , PG12ME, 6-keto-PGFldME were synthesized by chemical methods.

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