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Synthesis of tritium labelled 2-vinyl dihydrosphingosine-1-phosphate

✍ Scribed by Ahcene Boumendjel; Stephen P. F. Miller

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
275 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of [1,1,3‐^3^H]‐2‐vinyl dihydrosphingosine‐1‐phosphate is described. The key step in this synthesis is the reduction of methyl 2‐trifluoro acetamido‐2‐vinyl nonadecanoate‐3‐one by means of ^3^H‐calcium diborohydride. This compound was synthesized to determine whether 2‐vinyl dihydrosphingosine‐1‐phosphate inhibits the PLP‐dependent sphingosine‐1‐phosphate lyase irreversibly via covalent modification.

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