𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The synthesis of tritium labelled neurokinin-1 receptor ligands

✍ Scribed by Terence G. Hamill; H. Donald Burns

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
100 KB
Volume
47
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Radiolabelled neurokinin‐1 (NK~1~) receptor antagonists 1b and 2b were required for in vitro/in vivo characterization to support the development of 1a and 2a as fluorine‐18 labelled PET ligands. These tritium labelled compounds were synthesized from aryl iodide precursors giving the final tritiated tracers with specific activities of 28 (1b) and 14 (2b) Ci/mmol. Copyright © 2004 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

The synthesis of tritium-labelled azidot
The synthesis of tritium-labelled azidothymidine
✍ Sunil K. Aggarwal; David R. Shalinsky; Krishna C. Agrawal 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 209 KB

The synt esis of 3H-labelled azidothymidine (AZT) from accomplished by column chromatography. The purity of the labelled compound was determined by high performance 1 iquid chromatography connected with a radioactive flow detector. The labelled AZT was found to be stable at pH ranging from 2.3 to 7.

Synthesis of tritium labelled (R) and (S
Synthesis of tritium labelled (R) and (S)-3-aminoquinuclidine: A ubiquitous component of serotonin receptor ligands, part II
✍ Mohammad R. Masjedizadeh; Howard Parnes 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 398 KB 👁 2 views

S)-3-Aminoquinuclidine-3H 1 Oc-S having a specific activity of 66 Ci/mrnol was prepared in eight steps from lsonicotinic acid (2). Reduction of 2 with carrier free tritium gas over PtO2 In DMF gave isonipecotic acid-3H &. Conversion to a-bromo ketone followed by cyclization afforded 3-quinuclidone-

Synthesis of tritium labelled (R) and (S
Synthesis of tritium labelled (R) and (S)-3-aminoquinuclidine: A ubiquitous component of serotonin receptor ligands, part I
✍ Mohammad R. Masjedizadeh; Howard Parnes 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 546 KB

R) and (S)-3-aminoquinuclidines-3H with the specific activity of 35 Ci/mmol were prepared. Reduction of enamide 2 with carrier free tritium gas over RhCODCl dimer, (2S, 3s) Chiraphos in methanol gave yacemk amide &. Hydrolysis followed by resolution of the enantiomers with (R)-methyl benzyl isocyana

Synthesis of tritium labelled L783483 -
Synthesis of tritium labelled L783483 - a PPARδ ligand
✍ Gunnar Grue-Sørensen; Nicolaj Høj 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 86 KB

## Abstract The potent peroxisome proliferator‐activated receptor (PPAR) __δ__ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propy