✦ LIBER ✦

Synthesis of tritium labelled L783483 - a PPARδ ligand

✍ Scribed by Gunnar Grue-Sørensen; Nicolaj Høj

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 86 KB
Volume: 46
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.687

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluoromethyl‐benzisoxazole. [^3^H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Synthesis of tritium and carbon-14 label

Synthesis of tritium and carbon-14 labelled NNC 61-4655: a potent dual-acting PPARα and PPARγ agonist

✍ Steen K. Johansen; Lars Martiny 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB

## Abstract The synthesis of the potent dual‐acting PPARα and PPARγ agonist NNC 61‐4655 labelled with tritium and carbon‐14 is reported. Tritium labelled NNC 61‐4655 was obtained in three steps with introduction of tritium through catalytic tritium‐halogen exchange of an aryl bromide precursor. Thi

Synthesis of tritium-labelled cembrene-A

✍ Ambarish K. Singh; Glenn D. Prestwich 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 221 KB 👁 1 views

Commiphora s a p ( 3 1 , s o f t c o r a l s ( 4 1 , termite s o l d i e r s (5-8), t e r m i t e workers (9-101, and a n t s (11). Neither t h e b i o s y n t h e s i s of cembrene-A (presumably from g e r a n y l g e r a n y l pyrophosphate) nor i t s conversion i n t o any simple epoxide, d i o

Synthesis of tritium labelled precocenes

✍ A. Banerji; N. C. Goomer 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 200 KB 👁 1 views

## Abstract Regiospecific syntheses of tritium labelled precocene I (**5a**) and precocene II (**5b**), the antijuvenile hormones, have been accomplished. The syntheses involved condensations between 2‐hydroxyacetophenones (**1**) with acetone‐T to give cross condensation products **2** which on cy

Synthesis of tritium-labelled iohexol

✍ J. D. A. Herscheid; T. Jacobsen; K. Skinnemoen; J. Valk; A. Hoekstra 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 188 KB 👁 1 views

Synthesis of tritium labelled zaleplon

✍ V.P. Shevchenko; I.Yu. Nagaev; N.F. Myasoedov; A. Susan 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 73 KB 👁 1 views

## Abstract The reaction conditions for the incorporation of tritium into zaleplon have been investigated. The methods studied were the catalytic isotope exchange reaction with tritium gas and catalytic isotope exchange reaction with tritiated water. The results showed that the latter method was th

Synthesis of tritium labelled sparsomyci

Synthesis of tritium labelled sparsomycin

✍ Leon A. G. M. Van Den Broek; Kitty C. M. W. Willemsen; Irene H. G. Schlachter; H 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 249 KB 👁 1 views