✦ LIBER ✦

Synthesis of tritium labelled (R) and (S)-3-aminoquinuclidine: A ubiquitous component of serotonin receptor ligands, part I

✍ Scribed by Mohammad R. Masjedizadeh; Howard Parnes

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 546 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199601)38:1<41::aid-jlcr811>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

R) and (S)-3-aminoquinuclidines-3H with the specific activity of 35 Ci/mmol were prepared. Reduction of enamide 2 with carrier free tritium gas over RhCODCl dimer, (2S, 3s) Chiraphos in methanol gave yacemk amide &. Hydrolysis followed by resolution of the enantiomers with (R)-methyl benzyl isocyanate gave (R) and (S)-3-aminoquinuclidine-3H 1Oc-S and lOc-q. The enantiopurity purity of both isomers was >99.5%.

📜 SIMILAR VOLUMES

Synthesis of tritium labelled (R) and (S

Synthesis of tritium labelled (R) and (S)-3-aminoquinuclidine: A ubiquitous component of serotonin receptor ligands, part II

✍ Mohammad R. Masjedizadeh; Howard Parnes 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 398 KB 👁 2 views

S)-3-Aminoquinuclidine-3H 1 Oc-S having a specific activity of 66 Ci/mrnol was prepared in eight steps from lsonicotinic acid (2). Reduction of 2 with carrier free tritium gas over PtO2 In DMF gave isonipecotic acid-3H &. Conversion to a-bromo ketone followed by cyclization afforded 3-quinuclidone-

Synthesis of (R) and (S) 3-aminoquinucli

Synthesis of (R) and (S) 3-aminoquinuclidine-[3-14C] enantiomers, important components of a variety of 5-HT3 ligands

✍ Howard Parnes; Emma J. Shelton 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 460 KB 👁 2 views

3-Aminoquinuclidine, an important fragment associated with many 5-HT (serotonin) receptor ligands, has been synthesized using a 14Ccarbonation based sequence to prepare the starting material, isonicotinic 14C-acid (6). Elaboration of (6) to a-br~moacetyl-['~C] isonipecotic acid (Lp) via the correspo

Synthesis of tritium labelled 3(R)-HETE

Synthesis of tritium labelled 3(R)-HETE and 3(R),18(R/S)-DiHETE through a common synthetic route

✍ Natalya V. Groza; Igor V. Ivanov; Stepan G. Romanov; Valery P. Shevchenko; Nikol 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB

## Abstract An efficient procedure for the synthesis of 3‐hydroxyoxylipins labelled with tritium on all double bond positions is reported. The synthetic scheme involves a joint route for the formation of tetraacetylenic precursors followed by stereoselective reduction of the triple bonds either wit

Synthesis of labelled histamine H2-recep

Synthesis of labelled histamine H2-receptor antagonists I. Synthesis of deuterium, sulfur and tritium labelled cimetidine and metiamide by exchange

✍ T. Hesselbo; S. W. Slade; A. J. Villani; L. Petka 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 323 KB

The H -antagonists, metiamide and cimetidine were labelled 2 with deuterium and tritium in the 2-position of the imidazole ring by the uncatalyzed exchange reaction with deuterium and tritium oxide at 100°C. The sulfur-35 labelled metiamide was prepared by an exchange reaction with elemental sulfur-

Dopamine/Serotonin Receptor Ligands. Par

Dopamine/Serotonin Receptor Ligands. Part 4. Synthesis and Pharmacology of Novel 3-Benzazecines and 3-Benzazonines as Potential 5-HT2A and Dopamine Receptor Ligands.

✍ Hussein El-Subbagh; Thomas Wittig; Michael Decker; Sigurd Elz; Martin Nieger; Jo 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 117 KB 👁 2 views

Dopamine/Serotonin Receptor Ligands. Par

Dopamine/Serotonin Receptor Ligands. Part IV [1]: Synthesis and Pharmacology of Novel 3-Benzazecines and 3-Benzazonines as Potential 5-HT2A and Dopamine Receptor Ligands

✍ Hussein El-Subbagh; Thomas Wittig; Michael Decker; Sigurd Elz; Martin Nieger; Jo 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 2 views