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Synthesis of labelled histamine H2-receptor antagonists I. Synthesis of deuterium, sulfur and tritium labelled cimetidine and metiamide by exchange

✍ Scribed by T. Hesselbo; S. W. Slade; A. J. Villani; L. Petka

Publisher: John Wiley and Sons
Year: 1979
Tongue: French
Weight: 323 KB
Volume: 16
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580160312

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✦ Synopsis

The H -antagonists, metiamide and cimetidine were labelled 2 with deuterium and tritium in the 2-position of the imidazole ring by the uncatalyzed exchange reaction with deuterium and tritium oxide at 100°C. The sulfur-35 labelled metiamide was prepared by an exchange reaction with elemental sulfur-35 in refluxing pyridine and by the reaction of 2[(4-methyl-S-imidazolyl) methylthio]ethylamine with m e t h y l i s ~t h i o c y a n a t e -~~S in refluxing ethanol.

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